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Following drug administration, all groups of mice were given a pre-weighed amount of food (RD mice received chow and WD mice received both HFHS and chow) with free access to water
Kidneys are the natural filters for your body
This inefficient process produces excessive lactic acid, alters cellular pH, and causes microscopic muscle damage that can take days or weeks to repair
However, prolonged or high-dose ketamine exposure induces a compensatory upregulation of NMDARs, increasing intracellular calcium ion influx and ROS production, ultimately leading to neuronal apoptosis (Liu et al., 2013)
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